Curcumin is a substance found in turmeric, a spice with a rich history of use in cooking and folk medicine for thousands of years. It has been used in ancient Ayurveda medicine. Indians used as an antiseptic for cuts and burns, a remedy for gastrointestinal discomfort and respiratory conditions, and more. Curcumin inhibits the activity and synthesis of cyclooxygenase and 5-lipooxygenase (5-LOX), which are enzymes related to inflammation. The researchers discovered that curcumin profoundly helped reduce joint inflammation.